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HomeMedical NewsImpression of formative years experiences on late life cognitive outcomes … and...

Impression of formative years experiences on late life cognitive outcomes … and different analysis


  1. Tom Nolan, scientific editor; sessional GP, Surrey

  1. The BMJ, London

Tom Nolan critiques this week’s analysis

Adolescence circumstances and dementia

Dementia charges fluctuate significantly between completely different ethnic teams. Latest analysis estimated that black individuals within the UK are 22% extra prone to be recognized with dementia than white individuals. A cross-sectional examine of 1634 black and 7381 white individuals in a nationally consultant survey of adults over 50 years outdated within the US checked out formative years circumstances as a potential contributing issue to those variations. Within the US, state sponsored college segregation led to many black college students having shorter college days, shorter college years, and fewer entry to academic assets, and was solely outlawed in 1954. This examine estimated that faculty segregation was related to between 28.8% to 39.7% of the racial disparities in cognition, and that over 80% of the variations in cognitive impairment seen between black and white individuals was related to variations in formative years circumstances.

JAMA Intern Med doi:10.1001/jamainternmed.2024.1132

Energetic surveillance for localised prostate most cancers

The 2021 NICE tips advocate providing lively surveillance for localised prostate most cancers and decrease danger options (Cambridge Prognostic Group 1 and a pair of). A brand new multicentre cohort examine set in North America adopted 2155 males with low danger localised prostate most cancers who had been put onto an lively surveillance protocol. The ten 12 months fee of metastasis was 1.4% (95% CI 0.7% to 2%) and prostate cancer-specific mortality was 0.1% (0 to 0.4%). For context, total mortality was 5.1% (3.8% to six.4%) over the identical interval. These charges are a lot decrease than you’ll discover quoted within the NICE guideline (2% danger of demise from prostate most cancers at 10 years, for instance), however this will likely partly be as a result of variations in lively surveillance protocols. On this examine sufferers had confirmatory biopsies resulting in 23% having the prostate most cancers grade reclassified.

JAMA doi:10.1001/jama.2024.6695

Statins within the over 85s

A goal trial emulation examine compares outcomes in an actual world inhabitants who’re uncovered to an intervention with a management group. One such examine set in China has discovered that folks aged 85 years or over and not using a prior prognosis of heart problems had decrease charges of heart problems occasions over a 5 12 months interval when prescribed statins than did controls: a 4.4% danger discount (95% CI 1.4% to 7.5%). With the sort of examine, nevertheless, residual confounding may end up in vital variations between the therapy and management teams (equivalent to in food regimen and life-style components), which may imply that those that began statins had been at all times going to be much less prone to be recognized with heart problems.

Ann Intern Med doi:10.7326/M24-0004

An image of well being

The house web page of the New England Journal of Medication at present has a “earlier than therapy” and “after therapy” picture on it that places each personal hair loss clinic advert you’ve ever seen to disgrace. 5 individuals with autoimmune polyendocrine syndrome kind 1 (APS-1) had been handled with the Janus kinase (JAK) inhibitor ruxolitinib. All 5 had remission of signs of the uncommon illness, which embrace oral candidiasis, nail dystrophy, gastritis, enteritis, arthritis, Sjögren’s-like syndrome, urticaria, thyroiditis, and (as so dramatically demonstrated within the images) alopecia.

N Engl J Med doi:10.1056/NEJMoa23126

Renal operate and hypertension in kidney donors

I’m unsure what degree of proof I’d want to steer me to donate a kidney. Randomised managed trials aren’t going to occur, however good high quality potential cohort research would in all probability be sufficient to place my thoughts comfortable about the long run dangers. A multicentre cohort examine of 924 dwelling kidney donors and 396 non-donors regarded for variations in blood stress, estimated glomerular filtration fee (eGFR), and albuminuria between the 2 teams after seven years. Within the donor group eGFR dropped by a imply of 32 mL/min/1.73 m2 within the donor group after nephrectomy—as you may anticipate—however, slightly than then declining on the identical fee as non-donors, it fell by 1.4 mL/min/1.73 m2 (95% CI 1.2 to 1.5) much less per 12 months than non-donors. Blood stress was comparable in each teams on the finish of the examine.

JAMA doi:10.1001/jama.2024.8523

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